Sphingolipids are named for the enigmatic sphinx of ancient mythology because their functions in biology traditionally have been somewhat mysterious. In recent years, there has been increasing ...

Bioactive sphingolipids constitute a family of lipids, including sphingosine, ceramide, sphingosine-1-phosphate (S1P) and ceramide-1-phosphate. These molecules act on distinct protein targets, ...

Plasma ceramides and sphingomyelins with palmitic acid were linked to a 34% and 37% increased risk of sudden cardiac death (SCD) per higher SD of log sphingolipid levels, respectively. After looking ...

Sphingolipids are important biological molecules, a class of lipids that have a backbone of sphingoid bases including sphingosine (aliphatic amino alcohol) or another structurally similar compound. In ...

EPFL scientists have made the first link between muscular dystrophy and a group of bioactive fats, the sphingolipids, which are involved in numerous cell functions and other diseases. In a new study, ...

Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns. Fortunately, this ...

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is ...

The sphingolipids ceramide and sphingosine-1-phosphate (S1P) function as effector molecules, and have important roles in stimulus/agonist-mediated signalling and the regulation of many cellular ...

Sphingolipids are gaining strategic importance because they sit at the intersection of therapeutics, delivery science, and beauty biomimetics. In pharmaceuticals, their relevance is rising as research ...

Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment ...